Insertional inactivation of dsbA produces sensitivity to cadmium and zinc in Escherichia coli.
نویسندگان
چکیده
In a search for genes that produce hypersensitivity to cadmium salts in Escherichia coli, random transposon mutagenesis with TnphoA was used. One of the mutant strains obtained was sensitive to Cd2+ and Zn2+. Sequence analysis showed that the TnphoA insertion was located in the dsbA gene coding for a periplasmic protein required for disulfide bond formation.
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عنوان ژورنال:
- Journal of bacteriology
دوره 179 8 شماره
صفحات -
تاریخ انتشار 1997