Insertional inactivation of dsbA produces sensitivity to cadmium and zinc in Escherichia coli.

نویسندگان

  • C Rensing
  • B Mitra
  • B P Rosen
چکیده

In a search for genes that produce hypersensitivity to cadmium salts in Escherichia coli, random transposon mutagenesis with TnphoA was used. One of the mutant strains obtained was sensitive to Cd2+ and Zn2+. Sequence analysis showed that the TnphoA insertion was located in the dsbA gene coding for a periplasmic protein required for disulfide bond formation.

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عنوان ژورنال:
  • Journal of bacteriology

دوره 179 8  شماره 

صفحات  -

تاریخ انتشار 1997